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| Research on the preparation of “Ophthalmic Washing Solution No.1” Chinese traditional medicine liniment |
| Hits 1825 Download times 1374 Received:February 16, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.07.14 |
| Key Words
liniment;"Ophthalmic Washing Solution No.1" Chinese tratiditional medicine;orthogonal experimental design |
| Author Name | Affiliation | E-mail | | ZHANG Peng | Tianjin Eye Hospital, Tianjin 300022, China | | | LIU Mei-xin | Tianjin Eye Hospital, Tianjin 300022, China | lmxing1964@sina.com | | PANG Ya-ju | Tianjin Eye Hospital, Tianjin 300022, China | | | CHEN Hong-ying | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | ZHU Yong-zhi | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | CHEN Xi | Tianjin Eye Hospital, Tianjin 300022, China | |
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| Abstract
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| [Objective] To optimize the preparation process of different single factors such as dosage of accessories and addition way of medicine extracts in orthogonal experiment, to ensure the safety of "Ophthalmic Washing Solution No.1" Chinese traditional medicine liniment and establish a best one to ensure the safety.[Methods] To find the best preparation of the liniment by evaluating the film-forming time, flexibility, uniformity and fluidity and acute toxicity test on the basis of Chinese traditional medicine and natural medicine acute toxicity studies technical guidelines.[Results] The ratio in the best preparation of "Ophthalmic Washing Solution No.1" Chinese traditional medicine liniment which with the best film-forming time, flexibility, uniformity and fluidity was distilled water:ethanol:acetone:PVA:medicine extracts=5:2:1:1:1.[Conclusion] The preparation of "Ophthalmic Washing Solution No.1" Chinese traditional medicine liniment is reasonable, feasible and reliable. The film-forming time, flexibility, uniformity and fluidity can meet the requirements. |
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