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| The correlatation study between hippocampal cholinergic θ rhythm and spatial memory in rats under physiological and pathological conditions |
| Hits 1528 Download times 1527 Received:March 20, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.09.11 |
| Key Words
hippocampal θ rhythm;spatial learning and memory;amyloid β protein;Alzheimer's disease |
| Author Name | Affiliation | | LIU Xu | Department of Clinical Laboratory, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | YUE Xin-hua | Department of Clinical Laboratory, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | ZHENG Ya-ping | Department of Clinical Laboratory, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the correlation between hippocampal cholinergic θ rhythm and spatial learning and memory under physiological and pathological conditions, further clarify the association between the cognitive deficits and the hippocampal θ synchronization disorder. This article also wants to provide the experimental evidence evaluating the ability of spatial learning and memory in rodents by recording the hippocampal cholinergic θ rhythm. [Methods] Tai-pinch induced hippocampal cholinergic θ rhythm was recorded after Morris water maze test on the same SD rats. Main indicators including: the latencies in the hidden platform test, the percentage of swimming time in target quadrant in the probe trial test, the swimming speed and the latencies in the visible platform test, the peak power (Ppeak) and average peak frequency (Fpeak) of θ rhythm. [Results] Bilateral intrahippocampal injection of full length amyloid β peptide (Aβ-42) significantly impaired spatial learning (P<0.05) and memory (P<0.05) of rats in Morris water maze test and reduced the Ppeak of hippocampal cholinergic θ rhythm (P<0.05). In control group, there was a significant negative correlation between the Ppeak of hippocampal cholinergic θ rhythm and the escape latency (r=-0.803,P<0.05) and a significant positive correlation between the Ppeak of hippocampal cholinergic θ rhythm and the percentage of swimming time in target quadrant (r=0.762,P<0.05). Similar correlations were found with a correlation coefficient of r=-0.764 (P<0.05) and r=0.771 (P<0.05) respectively in Aβ1-42 injection group. Taken these as a whole,the Ppeak of hippocampal cholinergic θ rhythm was more correlated with escape latency (r=-0.896, P<0.01) and swimming time percentage (r=0.888, P<0.01). [Conclusions] There is strong correlation between the hippocampal cholinergic θ rhythm and the spatial learning and memory ability in rats, suggesting the somatosensory stimulation induced hippocampal cholinergic θ rhythm may be involved in the spatial learning and memory consolidation in rats. The power of hippocampal cholinergic θ rhythm may be an indicator to assess the ability of spatial learning and memory in rats. |
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