|
| Study on the relationship between the serum Copeptin level and the syndrome differentiation of traditional Chinese medicine in patients with chronic heart failure |
| Hits 1723 Download times 1423 Received:April 28, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.10.05 |
| Key Words
heart failure;differentiation of traditional Chinese medicine;copeptin;correlation |
| Author Name | Affiliation | E-mail | | LIU Yue | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | | | QI Xin | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | qixinx2011@126.com | | JIA Wen-jun | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | | | WEI Li-ping | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | | | LIU Ke-qiang | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | |
|
| Abstract
|
| [Objective] To evaluate the correlation between Copeptin which is the model marker of heart failure and syndrome differentiation of traditional Chinese medicine. [Methods] A prospective study was performed. Patients were consecutively collected 230 patients with coronary heart disease and hypertension admitted to department of cardiology were divided into three groups: NYHA Ⅱ group (case 82), NYHA Ⅲ group (case 76), NYHA IV group (case 72), and control group (case 51) with normal heart function. Combined with Guiding Principle of Clinical Research on New Drugs of Traditional Chinese Medicine and the common syndromes, 230 patients were divided into Heart- Qi - deficiency group (case 42), Qi - Yin deficiency group (case 64), Qi deficiency with syndrome of intermingled phlegm and blood stasis group (case 77), heart-kidney Yang deficiency group (case 47). Limosis vein blood sample of each patient was drawn in the morning. Serum concentrations of NT-proBNP, Copeptin and Estimation of left ventricular systolic function were detected. The serum Copeptin concentration and the serum NT-proBNP concentration were compared among all the groups. The relativity among the levels of NT-proBNP, the levels of Copeptin and NYHA classification were confirmed with linear correlation. [Results] The change of serum Copeptin and NT-proBNP were consistent in patients with heart failure. The serum NT-proBNP and Copeptin levels went up according to Heart- Qi - deficiency, Qi - Yin deficiency, Qi deficiency with syndrome of intermingled phlegm and blood stasis group, heart-kidney Yang deficiency in order. The Copeptin values was the highest in the heart-kidney yang deficiency group compared with Heart-Qi-deficiency group, Qi-Yin deficiency group and Qi deficiency with syndrome of intermingled phlegm and blood stasis group(pmol/L: 27.40(21.92,39.01), 18.80(16.23,21.94), 14.19(12.10,16.23), 8.93(7.35,11.75), P<0.05. Heart-Qi deficiency and Qi-Yin deficiency were prevalent among patients of NYHA Ⅱ, Qi deficiency with syndrome of intermingled phlegm and blood stasis were prevalent among patients of NYHAⅢ, heart-kidney Yang deficiency was prevalent among inpatients of NYHA IV. [Conclusion] The levels of serum NT-proBNP and Copeptin in patients with chronic heart failure may vary according to the severity of syndrome differentiation. It can provide the basis for the syndrome differentiation of traditional Chinese medicine and improve the accuracy of the syndrome differentiation. |
|
|
|
|
|
|
|
