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| Efficacy and safety of Xiaoyi formula in the treatment of endometriosis |
| Hits 1800 Download times 1488 Received:June 20, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.11.09 |
| Key Words
Xiaoyi formula;endometriosis;clinical effect observation;safety analysis |
| Author Name | Affiliation | E-mail | | LIU Xia | Shaanxi University of Chinese Medicine, Xianyang 712046, China | | | XIAO Xin-chun | Shaanxi University of Chinese Medicine, Xianyang 712046, China | xxchsd2003@163.com |
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| Abstract
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| [Objective] To observe the efficacy and safety of Xiaoyi formula in treating endometriosis.[Methods] The 60 patients diagnosed as endometriosis were randomly divided into two groups,30 cases of treatment group administered capsule of Xiaoyi formula and 30 cases of control group given gestrinone. The pain score was evaluated with Visual analogue scale (VAS). The size of endometrial cysts and resistance indexes (RI) of uterine arteries were evaluated with ultrasonography. The serum CA125 levels was determined by ELISA. The incidence of adverse reactions, which included to acne, dysfunction of liver, colporrhagia, dyslipidemia and weight gain, was also observed. The differences of these indicators were compared before and after treatment.[Results] The VAS scores, size of endometrial cysts as well as CA125 levels in both group decreased significantly,but the differences of the changes were not significant (P>0.05). The differences of the total effects rates were not statistically significant (P>0.05). RI in treatment group decreased significantly (P<0.05). The incidence adverse effects in treatment group were significantly lower than the control group (P<0.05).[Conclusion] Clinically, Xiaoyi formula is as effective as gestrinone capsules, and it is safer than gestrinone capsules. |
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