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| Study of the behavioral improvement effects of Xueshuantong for injection on vascular dementia rats |
| Hits 2013 Download times 1480 Received:April 26, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.11.12 |
| Key Words
vascular dementia;behavioral test;water morris;Xueshuantong for injection |
| Author Name | Affiliation | E-mail | | WANG Jin-xin | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Hong-yun | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Hong | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHAI Li-juan | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Yue | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Shao-xia | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | wangshaoxia1@163.com | | HU Li-min | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To research the behavioral improvement effects of Xueshuantong for injection (lypolized) in curing vascular dementia (VD) rats.[Methods] SD rats were randomly divided into 4 groups (n=20 per group):Sham group, Model group, Tacrine (Control) group and Xueshuantong group. All groups in addition to sham group received a surgery called bilateral common carotid artery occlusion (BCCAO) to establish VD models. The survival quality of all rats was recorded. Water morris and Y-maze were taken to be behavioral test.[Results] Compared with model group, there was no statistical significance among all groups in death rate and weight's change of rat. Compared with sham group, learning and memory ability of model group dropped with a reduced number of crossing the platform (P<0.01) in water morris test. Compared with model group, Xueshuantong could increase the number of crossing the platform (P<0.01) in water morris test which is the same as Tacrine group. Compared with model group, spatial memory ability of low dose group (Xueshuantong) obviously improved in Y-maze test.[Conclusion] Xueshuantong for injection (lypolized) could improve learning and memory ability of VD rats. |
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