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| Effect of Qipo Shengmai granules on cardiac function in mice models of heart Qi deficiency syndrome |
| Hits 1888 Download times 1679 Received:June 05, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.11.13 |
| Key Words
Qipo Shengmai granule;heart Qi deficiency;heart function |
| Author Name | Affiliation | E-mail | | CHEN Wen | Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China | | | HU Yuan-hui | Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China | gamwendy@163.com | | SHI Shuai | Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China | | | SHI Jing-jing | Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China | | | WANG Yan-yun | Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China | |
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| Abstract
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| [Objective] Applied with echocardiography to observe the heart function change of heart Qi deficiency mice and evaluate the effect of Qipo Shengmai granules.[Methods] The model of heart Qi deficiency in mice was established by the method of controlling food, forced swimming and given large dose of propranolol. Kunming mice were randomly divided into normal control group, model group, positive control group and Qipo Shengmai granules high/medium/low dose group. After 14 days of administration, the changes of cardiac function refers to LVIDs, LVIDd, LVPWd, LVPWs, IVSd, IVSs, LVEDV, LVESV, EF, FS, in mice were determined.[Results] Compared with the model group and positive control group, the cardiac function of model group was significantly decreased. Compared with the positive control group, Qipo Shengmai granules high/medium dose group heart function improved significantly (P<0.05 or P<0.01).[Conclusion] Qipo Shengmai granules improves cardiac function in heart Qi deficiency mice. |
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