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| Relationship between astrocytes mediated gliovascular coupling and the blood-brain barrier damage in alzheimer's disease |
| Hits 1837 Download times 1618 Received:June 30, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.11.17 |
| Key Words
alzheimer's disease;blood-brain barrier;astrocyte;gliovascular coupling |
| Author Name | Affiliation | E-mail | | ZHANG Yun-sha | Department of Pathology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Hu-hu | Department of Pathology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DU Huan | Department of Pathology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Ying-chang | Department of Pathology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | 29159173@qq.com |
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| Abstract
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| The blood-brain barrier (BBB) plays critical roles in the maintenance of central nervous system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases, including alzheimer's disease (AD). Astrocyte mediated gliovascular coupling play essential roles in BBB feature induction and maintenance. So, changes about astrocyte polarity and paracrine function may result in BBB dysfunction.The polarity distribution of aquaporins4 and Sonic Hedgehog (SHH) pathway are gotten more attention in gliovascular coupling, hence the review focus on the role of aquaporins 4 and SHH pathway in BBB and the potential contribution of gliovascular coupling abnormal changes to BBB dysfunction in AD. At last, we conclude that improving the AC's response to amyloid β, regulating the gliovascular coupling will be a new idea for the prevention and treatment of AD. |
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