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| Antidepressant effect of Jiaotai pills in mice model of depression induced by reserpine |
| Hits 1775 Download times 1391 Received:July 06, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.12.10 |
| Key Words
Jiaotai pivll;monoamine neurotransmitter;depression |
| Author Name | Affiliation | E-mail | | YU Ze-sheng | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | PAN Ye | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | SONG Yan-qi | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Min | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Ran | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Shu-ming | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Lin | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Shan | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | bianjibugs@163.com | | YU Chun-quan | Tianjin Uniersity of Traditional Chinese Medicine, Tianjin 300193, China | ycq-4@163.com |
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| Abstract
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| [Objective] To study the effect of Jiaotai pills on depressive model of mice induced by reserpine.[Methods] In the present study,we used forced swimming test,tail suspension test and reserpine antagonistic test to explore the antidepressant effect of Jiaotai pill,and the monoamine neurotransmitters(NE,5-HT,5-HIAA) content changes of hippocampus and cortex were measured by HPLC.[Results] The dosage of Jiaotai pill could significantly reduce the immobility time of forced swimming test and tail suspension experiment,And can antagonize reserpine induced ptosis and body temperature decline in mice,and can reverse NE and 5-HT reduction and reduce the 5-HIAA content.[Conclusion] Jiaotai Pill has obvious antidepressant effect,and can play an antidepressive effect by regulating the contents of NE and 5-HT in the hippocampus and cortex. |
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