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| Advance of mass defect filter technique by high-resolution mass spectrometry |
| Hits 3201 Download times 2108 Received:May 01, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.12.16 |
| Key Words
mass defect filter;metabolites identification;traditional Chinese medicine ingredient identification |
| Author Name | Affiliation | E-mail | | HOU Yan-ting | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | WANG Xiao-ming | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Jia-wei | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | PAN Gui-xiang | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | guixiangp@163.com |
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| Abstract
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| In recent years,with the development of the high resolution mass spectrometry,its application in medical field has expanded,followed by the development and exploitation of the related data mining techniques of mass spectrometry,such as extract ion chromatography technology,neutral lost filtering technology,and product ion filtering technology.In all of those methods,a novel date filtering technology,the mass defect filter (MDF) which is produced by processing and identifying the collected dates according to the similarity mass defect between prototype drugs and its metabolites can select and identify drug and its metabolites from complex matrix via once or limited injection.And it had shown greatest advantage in this field. |
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