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| An outlook on research and development of multi-target, synergistic acting anti-arrhythmia compound medicine: progress and case study of Wenxin Keli |
| Hits 5573 Download times 2326 Received:September 13, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2017.01.04 |
| Key Words
Wenxin Keli;arrhythmia;pharmacological mechanism;ion channel;electrophysiology |
| Author Name | Affiliation | E-mail | | WANG Tai-yi | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | YAO Xi | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | XIE Wei-wei | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | CUI Ying | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | ZHU Yan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | yanzhu.harvard@icloud.com |
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| Abstract
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| Wenxin Keli (WK), a Chinese patent medicine, is known to be effective for cardiac arrhythmias and heart failure. According to traditional Chinese medicine theory, WK is suitable for treating Yin deficiency, systolic blood stasis of heart palpitations, and pulse knot generation. Symptoms refer shortness of breath, fatigue, restlessness, palpitations, dizziness, irritability, chest pain, pulse knot generation or imaginary. pharmacological investigations on WK has been on going, particularly with some of the most important findings achieved recently. In this paper, we summarize the research progress of WK pharmacology to date, focusing on cardiac electrophysiological discoveries, and discuss the rationality and need of a multi-target, coordinative regulation capability ofantiarrhythmiccompound medicine. |
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