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| Influence of the inositol-requiring enzyme 1a(IRE1α) in the liver getted mice with type 2 diabetes mellitus and hyperlipidemia after treatment by the fortune's eupatoium herb |
| Hits 2420 Download times 1593 Received:November 14, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2017.03.12 |
| Key Words
fortune's eupatorium herb;nositol-requiring enzyme 1α;type 2 diabetes mellitus;hyperlipidemia |
| Author Name | Affiliation | E-mail | | XUE Chao | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HE Bai-chuan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HAN Yi-yi | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Qing-hua | The First Affiated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WU Shen-tao | The First Affiated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | shtaowu@163.com |
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| Abstract
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| [Objective] To reserch the influence of inositol-requiring enzyme 1α(IRE1α) in liver getted mice with type 2 diabetes mellitus and hyperlipidemia after treatment by fortune's eupatorium herb.[Methods] The successful builted mice were randomly assigned into four groups, model group feed by 2 mL/d saline, peilan treatment group feed by fortune's eupatorium herb 3 g/(kg·d) and pioglitazone treatment group feed by pioglitazone in 0.3 mg/(kg·d), and 10 normal mice were sized to be a group. Mice were treated for 5 weeks, and the blood glucose, triglyceride, cholestenone and insulin were invested, then the expression of the IRE1α's mRNA and protein were invested.[Results] Compared with the model group,the triglyceride and cholestenone in fortune's eupatorium herb treatment group turned to be better, and the impression of mRNA and protein in liver was lower.[Conclusion] Fortune's eupatorium herb can improve the content of IRE1α in the organs of mice with type 2 diabetes mellitus and hyperlipidemia. |
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