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| Study on effect and mechanism of iridoid glycoside from cornus officinalis on mice with nonalcoholic liver injury and insulin resistance |
| Hits 1788 Download times 1334 Received:November 25, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2017.03.14 |
| Key Words
iridoid glycoside from cornus officinalis;liver injury;insulin resistance;effect mechanism |
| Author Name | Affiliation | | WANG Shi-wei | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | XU Ning | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the effect and mechanism of iridoid glycoside from cornus officinalis (ICO) on insulin resistance and nonalcoholic liver injury in mice.[Methods] Mice were divided into normal group, model group, Pioglitazone group, ICO low, middle and high dose group, administrating for 3 weeks respectively. Mice were fed with high-fat diet (HFD) to induce obesity and diabetes. The level of ALT, AST, TC, TG, LDL, HDL, insulin, TNF-α,IL-6 and IL-1β were measured by ELISA method, expression level of p-P65,p-ERK1/2,p-JNK1/2 and p-P38 were detected by Western Blot method.[Results] Administration of ICO can significantly reduced the fat index, the level of serum ALT, AST, TC, TG, LDL, HDL, insulin, TNF-α, IL-6 and IL-1β, the expression level of p-P65,p-ERK1/2,p-JNK1/2 and p-P38 and improved glucose and insulin tolerance of the obese mice.[Conclusion] ICO can improve insulin resistance and nonalcoholic liver injury in mice significantly. The effect may be acted through reduce the expression level of p-P65,p-ERK1/2,p-JNK1/2 and p-P38, then inhibit NF-κB and MAPK pathway activation and inflammatory reaction. |
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