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| Advances study of phytoestrogen from licorice |
| Hits 2917 Download times 1559 Received:December 03, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2017.03.18 |
| Key Words
licorice;flavonoids;phytoestrogen;estrogen receptor |
| Author Name | Affiliation | E-mail | | HAN Jing | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biotechnology and Medicine, Research and Development Center of Traditional Chinese Medicine, Tianjin 300457, China | | | SHAO Rui | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biotechnology and Medicine, Research and Development Center of Traditional Chinese Medicine, Tianjin 300457, China | | | WANG Yue-fei | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biotechnology and Medicine, Research and Development Center of Traditional Chinese Medicine, Tianjin 300457, China | | | WANG Yu | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biotechnology and Medicine, Research and Development Center of Traditional Chinese Medicine, Tianjin 300457, China | wangyu@tjutcm.edu.cn |
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| Abstract
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| Licorice, isolated from Fabaceae Glycyrrhiza, is an essential traditional Chinese medicine. Flavonoids and triterpenoids play main roles among 400 compounds, identified from Licorice. Due to phytoestrogenic activity, flavonoids are broadly used for clinical treatment, including breast cancer, neuropathic, cardiovascular and other various diseases via PI3K/Akt and MAPK pathways. This review focuses on the molecular mechanisms and clinical applications of phytoestrogen from licorice, based on database of China National Knowledge Infrastructure(CNKI) and PubMed, which sheds lights on the clinical treatment and drug discovery of phytoestrogen from licorice. |
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