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| Intervention of Aconite Main Tuber decoction on NGF,TrkA and p75NTR in rats developed diabetic peripheral neuropathy |
| Hits 1949 Download times 1359 Received:December 16, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2017.04.14 |
| Key Words
Aconite Main Tuber decoction;diabetic peripheral neuropathy;nerve growth factor;TrkA;75NTR |
| Author Name | Affiliation | E-mail | | CUI Han-bo | Department of Diabetes, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | CHU Yue-jie | Department of Diabetes, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | chuyj2002@hotmail.com | | REN Yong-li | Department of Diabetes, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | Li Ping | Department of Diabetes, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | |
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| Abstract
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| [Objective] To study the effect and mechanism of Aconite Main Tuber Decoction on NGF,TrkA and p75NTR in rats developed diabetic peripheral neuropathy(DPN). [Methods] To set up pathological model of DPN, wistar rats were given streptozotocin (STZ) by intraperitioneal injection. NGF in serum and TrkA, p75NTR in tibial nerve tissue were observed. [Results] Compared with blank control group, FBG were higher in both before and after the intervention groups and Aconite Main Tuber Decoction group (P<0.01). No significant difference in FBG within the groups before and after intervention (P>0.05). Compared with model control group, NGF in serum were higher and p75NTR in tissue were lower in medicinal group(P<0.05). In medicinal group,immunohistochemistry showed a lower degree positive staining compared with model control. [Conclusion] Aconite Main Tuber Decoction could alleviate DPN by regulating p75NTR/TrkA balance and rising NGF concentration. |
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