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| Observation of clinical curative effect and security of Tongbi capsule in treating rheumatoid arthritis (syndrome of cold-dampness blocking the channals and collaterals) |
| Hits 2203 Download times 1472 Received:March 03, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.07.04 |
| Key Words
Tongbi capsule;rheumatoid arthritis;syndrome of cold-dampness blocking the channals and collaterals;clinical curative effect;security |
| Author Name | Affiliation | E-mail | | WANG Xiao-lei | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | WU Ye | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | wuy991@163.com | | YU Xiao-xia | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | XU Ping | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | PING Li-feng | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | SUN Feng-yan | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | HU Li-wei | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | |
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| Abstract
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| [Objective] To observe the clinical effectiveness and safety of the Tongbi capsule in treating rheumatoid arthritis(syndrome of cold-dampness blocking the channals and collaterals). [Methods] The 100 cases of rheumatoid arthritis (syndrome of cold-dampness blocking the channals and collaterals) of patients were randomly divided into two groups, 50 cases in each group. The control group were treated with LEF+MTX, while the treatment group were based on the Tongbi capsule treatment. Observed two groups of curative effect of TCM syndrome before and after therapy, Chinese medicine clinical symptoms integral, ACR20, ACR50, IL-1, IL-6, the changes of TNF-α, at the same time observe the blood routine, liver and kidney function safety indexes such as changes in order to understand the clinical application of security. [Results] Treatment group can significantly reduce the clinical symptoms of traditional Chinese medicine integral (P<0.05), especially in the numbness, afraid of cold symptoms such as improving. Performance was particularly significant difference. One year after treatment in treatment group ACR20, ACR50 respectively 88%, 74%, significantly higher than the control group were 66%, 60% (P<0.05). Tongbi capsule can better reduce the IL-1, IL-6, the content of TNF-α, can significantly reduce and alleviate the clinical symptoms of patients. In the two groups in safety indexes such as liver and kidney function, no significant differences in the comparison of the safety tips curative effect of two groups. [Conclusion] Based on joint slow-acting drug treatment with Tongbi capsule treat syndrome of cold-dampness blocking the channals and collaterals arthritis with syndrome of cold-dampness blocking the channals and collaterals to improve the chills, numbness syndrome of traditional Chinese medicine has good effect, has good clinical efficacy and safety. |
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