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| Retrospective analysis on characteristics of traditional Chinese medicine syndrome and influence factors related to early onset of rheumatoid arthritis-associated interstitial lung disease |
| Hits 1566 Download times 1261 Received:March 24, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.08.04 |
| Key Words
rheumatoid arthritis;interstitial lung disease;traditional Chinese medicine syndrome;influence factor |
| Author Name | Affiliation | E-mail | | ZHANG Lei | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Qi | Tinjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Wen | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | liumintcm@163.com | | WU Yuan-hao | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To investigate the characteristics of traditional Chinese medicine (TCM) syndrome and influence factors related to early onset of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).[Methods] Clinical data, such as gender, age, smoking history, symptoms and signs, TCM syndrome, diagnostic time for RA and RA-ILD and characteristics of chest HRCT, of inpatient with RA-ILD, were analyzed retrospectively. Onset time, pathological types and influence factors related to early onset of RA-ILD were evaluated.[Results] A total of 130 patients were filtered and 11 patients were deleted. So 119 patients were identified, of whom 54 liver-kidney yin deficiency type, 36 asthenia of qi and blood type, 19 beriberoid pyretic arthralgia type and 10 wind-cold-damp retention type. The mean and median onset time respectively were 11 years and 7 years of these patients, and both of them showed a trend as beriberoid pyretic arthralgia type < wind-cold-damp retention type < asthenia of qi and blood type < liver-kidney yin deficiency type with significant differences. UIP (65.5%) and NSIP (30.3%) were the main pathological types. Iincidence rate of beriberoid pyretic arthralgia type (52.6%) and liver-kidney yin deficiency type(96.3%) in UIP and wind-cold-damp retention type(90.0%) and asthenia of qi and blood type(55.6%) in NSIP were significant higher. The results of multivariate Cox proportional hazards regression analysis showed that TCM syndrome of RA was the influence factor related to early onset(≤ 7 years) of RA-ILD, and excess syndrome of RA raised the risk two times.[Conclusion] There is a certain degree of correlation between TCM syndrome of RA and pathological type of RA-ILD, and onset times of RA-ILD of beriberoid pyretic arthralgia type and wind-cold-damp retention type are earlier than the other types. This conclusion should be further confirmed by prospective studies. |
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