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| Studies on differences between Fufang Danshen tablets and Fufang Danshen adhesion pellets release in vitro |
| Hits 1556 Download times 1139 Received:April 24, 2017 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2017.08.19 |
| Key Words
Fufang Danshen adhesion pellets;Fufang Danshen tablets;release in vitro |
| Author Name | Affiliation | E-mail | | CHEN Xiao-nan | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | LI Dan-qi | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | ZHAO Meng-di | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | DU Shou-ying | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | dushouying@263.net | | LU Yang | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | LI Peng-yue | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | |
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| Abstract
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| [Objective] Establish an HPLC method to determinate salviaacidB,tanshinoneⅡA and four panaxsapoins:Notoginsenoside R1, ginsenoside Rg1,ginsenoside Rd,ginsenoside Rb1in FufangDanshen adhesion pellets. Meanwhile, compare release difference of the two dosage form in vitro.[Methods] The pellets of compound salvia miltiorrhiza were prepared by extrusion-spheronization method. The dissolution rate of the six components in vitro and the dissolution rate and cumulative dissolution rate of compound Danshen Tablets and adhesive pellets were compared by using the phosphate buffer solution with pH6.8.[Results] Content of notoginsenoside R1 in Fufang Danshen adhesion pellets and Fufang Danshen tablets was 4.02% and 2.19%, ginsenoside Rg1 was 22.31% and 8.73%; ginsenoside Rb1 was 14.33% and 7.69%; ginsenoside Rd was 3.29% and 1.56%; salviaacid B was 17.41% and 21.70%; tanshinone ⅡA was 0.34% and 1.17%. The dissolution results showed that the total dissolution rate of the six components in the compound Danshen tablets can reach 90% within 120min, compared with the sustained release of the components of the pellets, and release in the release medium.[Conclusion] Compared with compound Danshen tablets and Compound Danshen Adhesive Pellets, the retention time in vivo is long, the release rate is slow and prolonged, and the drug action time can be prolonged, which indicated pellets can be sustained release in vivo. |
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