|
| Study on the protective effects of Qishen Yiqi pill on myocardial ischemia reperfusion injury in rats |
| Hits 1490 Download times 1224 Received:April 08, 2017 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2017.10.13 |
| Key Words
myocardial ischemia reperfusion injury;antiplatelet activation;cardiac function;Qishen Yiqi pill |
| Author Name | Affiliation | E-mail | | CHEN Jing-rui | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WEI Jing | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | NI Jing-yu | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Min | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Guan-wei | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | fgw1005@hotmail.com |
|
| Abstract
|
| [Objective] To investigate the effect and mechanism of Qishen Yiqi pills on myocardial function in rats with myocardial ischemia reperfusion injury.[Methods] The rat model of myocardial ischemia-reperfusion injury was established after 7 days of pre-intervention of Qishen Yiqi pills. At the end of reperfusion, the changes of left ventricular function were observed by echocardiography, and left ventricular catheterization was used to detect the hemodynamics of rats. Also, the contents of 6KPG, TXB2, PF-4, E-selectin, β-TG, FIB and cAMP in rat plasma were detected.[Results] Echocardiography and hemodynamics results showed that Qishen Yiqi pills could significantly increase EF and FS and improve hemodynamics in IRI rats. Qishen Yiqi pills could significantly increase the content of 6KPG and cAMP, reduced TXB2, PF-4, β-TG and E-selectin content in IRI rat plasma, maintaining 6KPG/TXB2 levels.[Conclusion] The pre-intervention of Qishen Yiqi pills can improve the cardiac function of IRI rats and reduce the myocardial ischemia-reperfusion injury, and its mechanism is related to the inhibition of platelet activation. |
|
|
|
|
|
|
|
