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| Effect of Chinese herbal medicine of Xintong Changluo on the migration of vascular smooth muscle cells in rats |
| Hits 1247 Download times 1196 Received:July 20, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.10.14 |
| Key Words
chronic kidney disease;Chinese herbal medicine of Xintong Changluo;migration;vascular smooth muscle cell |
| Author Name | Affiliation | E-mail | | YANG Xiao-kun | Emergency Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Xiao-wei | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Meng | The First Hospital of Baoding city, Baoding 071000, China | | | XIAO Xue-feng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | kai1219@163.com |
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| Abstract
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| [Objective] To observe the effect of Chinese herbal medicine of Xintong Changluo on the migration of vascular smooth muscle cells (VSMCs).[Methods] VSMCs was cultured in serum of rats with different concentrations of Xintong Changluo (10%, 20%, 30%), normal rats' serum was used as control group. The VSMCs migration was observed by scratch test and Boyden chamber method. The expression of MMP-2 and MMP-9 protein was detected by Western blot.[Results] Serum containing Xintong Changluo can inhibit the migration of VSMCs and the expression of MMP-2 and MMP-9 proteins, and the inhibitory effect was concentration dependent.[Conclusions] Xintong Changluo can inhibit the migration of VSMCs, and the mechanism may be related to its influence on the expression of MMP-2 and MMP-9. |
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