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| Evodia rutaecarpa protects against the irritability gastric ulcer in rats |
| Hits 1415 Download times 1450 Received:April 21, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.10.15 |
| Key Words
Evodia rutaecarpa;irritability;gastric ulcer;epinephrine |
| Author Name | Affiliation | E-mail | | GAO Yun-hang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | NIU Zi-chang | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MAO Hao-ping | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | haoping_mao@126.com |
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| Abstract
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| [Objective] To investigate the effect of Evodia rutaecarpa in irritability gastric ulcer of rats and its possible mechanism.[Methods] Wistar rats were randomly divided into normal control group, water-immersion restraint stress induced gastric ulcer model group, model and Evodia rutaecarpa 0.45 g/kg group, Evodia rutaecarpa 0.9 g/kg group, and Evodia rutaecarpa 1.8 g/kg group, calculate the gastric ulcer index of rats in each group. The level of serum epinephrine in rats was detected by high performance liquid chromatography with electrochemical method.[Results] Evodia rutaecarpa 0.45 g/kg group could significant reduce ulcer index (P<0.05) and inhibit ulcer formation. Compared with model group, every Evodia rutaecarpa group could definitely inhibit E content in serum.[Conclusion] Evodia rutaecarpa had the effect on inhibition of the irritability gastric ulcer, and its mechanism can be related to regulate content in serum. |
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