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| Effects on Yangxin decoction of myocardial AI and LVEF of chronic heart failure model rats |
| Hits 1967 Download times 1523 Received:May 21, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.11.13 |
| Key Words
Yangxin decoction;AI;LVEF;CHF;adriamycin |
| Author Name | Affiliation | E-mail | | YU Hai-rui | Heilongjiang University of Chinese Medicine, Harbin 150000, China | | | SUN Jing | Heilongjiang University of Chinese Medicine, Harbin 150000, China | ariayu1110@gmail.com |
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| Abstract
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| [Objective] Through the establishment of chronic heart failure rat model to observe effects on Yangxin decoction of AI and LVEF of chronic heart failure model rats.[Methods] The 70 male SD rats randomly selected 10 rats as control group, and the remaining 60 rats received intraperitoneal injection of adriamycin 4 mg/kg weekly for 6 weeks. After 6 weeks, all the rats measured the heart function, with LVEF<60% for heart failure model was established successfully. The rat model was established successfully were randomly divided into model control group, Yangxin decoction group and captopril group by random numbers. The blank control group, model control group distilled water with equal volume. Yangxin decoction group treated with Yangxin decoction extract 8.1 g/(kg·d) daily. Captopril group with captopril 2.25 mg/(kg·d) daily, administered for 4 weeks. After 4 weeks, all the rats were measured the AI and HE, LVEF staining to observe the myocardial tissue morphological changes.[Results] Compared with the blank control group, model control group rats myocardial AI increased, LVEF decreased, myocardial cell edema, muscle fiber fracture defext, karyopyknosis, uneven cytoplasm, interstitial infiltration of inflammarory cells. The difference was statistically significant (P<0.05). Compared with the model group, decoction group, raise heart myocardial AI captopril group rats decreased, and LVEF increased. Myocardial cells were arranged in order,normal morphology, cisible horizontal and vertical lines, reduce exudation, visible fracture defect. The difference was statistically significant (P<0.05). Compared with the captopril group, Yangxin decoction group rats myocardial AI, LVEF, myocardial HE staining, and there was no significant difference significance(P>0.05).[Conclusion] Yangxin decoction can inhibit chronic heart failure myocardial tissue of rats with AI, increased LVEF, reduce myocardial cell injury, and treat chronic heart failure in heart failure rats. |
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