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| Preparation and characterization of quercetin-tetrandrine nanoparticle and evaluation in vitro and in vivo |
| Hits 2451 Download times 1485 Received:July 20, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.11.15 |
| Key Words
quercetin;tetrandrine;nanoparticle;anti-oxidant;ultrasonic atomization |
| Author Name | Affiliation | E-mail | | CHEN Yi-bing | Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CUI Yuan-lu | Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | cuiyl@tju.edu.cn |
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| Abstract
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| [Objective] To prepare a nanoparticle to improve the bioavailability and antioxidant activity of quercetin and tetrandrine.[Methods] The quercetin-tetrandrine-nanoparticle (QU-TE-NP) was prepared by reverse microemulsion method. The QU-TE-NP was characterized by particle size and zeta potential analysis, transmission electron microscope (TEM), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FT-IR). The drug loading and encapsulation efficiency were measured by high performance liquid chromatography (HPLC). The antioxidant activities of quercetin and QU-TE-NP were compared by DPPH radical scavenging experiment.[Results] The nanoparticles formed a stable new phase by cross-linking. The average particle size was (38.86 ±1.81) nm and the Zeta potential was (-15.9±4.1) mV. The drug loading and entrapment efficiency of quercetin and tetrandrine were (0.98±0.04)%, (2.75±0.07)%, (96.80±1.10)%, (94.80±0.90)%, respectively. The antioxidant activity of QU-TE-NP was superior to quercetin.[Conclusion] The QU-TE-NP formulation enhanced the water-solubility of quercetin and tetrandrine, resulting in improved antioxidant capacity. |
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