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| Improvement of Isoquercitrin on liver fatty acid metabolism-related gene expression in db/db mice |
| Hits 1698 Download times 1457 Received:June 14, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2017.11.17 |
| Key Words
Isoquercitrin;fatty acid metabolism;gene expression |
| Author Name | Affiliation | E-mail | | XU Guang-yuan | Department of Endocrinology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | | | SUN Wen | Institute of Health cultivation, Beijing University of Chinese Medicine, Beijing 100029, China | | | SONG Zi-lin | Institute of Health cultivation, Beijing University of Chinese Medicine, Beijing 100029, China | | | GUO Xuan | Institute of Health cultivation, Beijing University of Chinese Medicine, Beijing 100029, China | | | WU Li-li | Institute of Health cultivation, Beijing University of Chinese Medicine, Beijing 100029, China | | | QIN Ling-ling | Institute of Health cultivation, Beijing University of Chinese Medicine, Beijing 100029, China | | | HOU Dan | Department of Geriatrics, The First Affiliated Hospital of Shaanxi University of traditional Chinese Medicine, Xianyang 712000, China | | | ZHANG Zhuo | Department of Geriatrics, The First Affiliated Hospital of Shaanxi University of traditional Chinese Medicine, Xianyang 712000, China | | | TIAN Shuo | Department of Geriatrics, The First Affiliated Hospital of Shaanxi University of traditional Chinese Medicine, Xianyang 712000, China | | | LI Xiang | Medical College of Hebei University of Engineering, Handan 056000, China | | | LIU Tong-hua | Institute of Health cultivation, Beijing University of Chinese Medicine, Beijing 100029, China | thliu@vip.163.com |
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| Abstract
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| [Objective] To investigate the effects and mechanisms of Isoquercitrin on liver fatty acid metabolism.[Methods] The 8 week old male db/db mice were randomly divided into two groups, control group and Isoquercitrin group. The 6 male C57BL/6J mice were used as normal group. Examinations were performed, including body weight, serum glucose, lipid, histopathology and expression of mRNA after a 4-weektreatment period.[Results] Compared with the Control group, Isoquercitrin group body weight, FBG, CHO, TG, FFA, liver weight, liver weight/body weight of mice decreased significantly (P<0.05 or P<0.01), and improved fat deposition of liver tissue by histological examination. The expression of SREBP1c, FAS mRNA in liver of Isoquercitrin group decreased (P<0.05 or P<0.01), PGC1α, PPARα mRNA expression was significantly increased (P<0.05).[Conclusion] The effect of Isoquercitrin improving the db/db mice fatty acid metabolism may be by down-regulating the expression of SREBP1c, FAS mRNA, and up-regulating the expression of PGC1α, PPARα mRNA. |
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