|
| Study on Chaiqi decoction on intestinal injury in rats with metabolic syndrome |
| Hits 1528 Download times 1369 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2017.12.12 |
| Key Words
metabolic syndrome;intestinal damage;soothing liver and strengthening spleen;Chaiqi decoction;inflammatory response |
| Author Name | Affiliation | E-mail | | ZHANG Jia-yan | Department of Spleen and Stomach, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China | | | LIU Yang | Department of Spleen and Stomach, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China | | | YUAN Wen-ling | Department of Spleen and Stomach, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China | | | GAO Yi-ge | Department of Spleen and Stomach, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China | | | ZHANG Li-ping | Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China | lpzhang2005@126.com |
|
| Abstract
|
| [Objective] To observe the effects of Chaiqi decoction on intestinal injury of metabolic syndrome rats mode.[Methods] The forty SDF male SD rats were randomly divided into normal group, model group, traditional Chinese medicine group, western medicine group. The rat model was established by feeding high fat, high sugar and high salt diet. The Chinese medicine, Western medicine group were respectively given Chaiqi decoction, pioglitazone hydrochloride suspension from the beginning of modeling. Normal and model groups were given Physiological saline for 16 weeks. The blood glucose, blood lipids and insulin were detected at 16th week, evaluation the insulin resistance. At the same time, measure blood pressure in rats. Measure and calculate the small intestine propulsion rate. HE staining was used to observe the pathological changes of intestinal tract, to assess the degree of intestinal injury. The expression of NF-κB protein in small intestine was detected by Western blot.[Results] The blood glucose, blood lipids, insulin, insulin resistance index, IL-6, TNF-α, blood pressure in Chinese medicine Chaiqi decoction group were significantly lower than the model group, higher than the normal group(P<0.05). Chaiqi decoction can improve the rate of small intestine, improve intestinal pathological damage.[Conclusion] Chaiqi decoction can improve metabolic syndrome in rats with glucose and lipid metabolism disorders, reduce metabolic syndrome, the extent of intestinal damage, delay its progress. |
|
|
|
|
|
|
|
