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| Chemical constituents from the roots of Asarum heterotroprides var. mandshuricum |
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| DOI
10.11656/j.issn.1672-1519.2017.12.15 |
| Key Words
Asarum heterotroprides var.mandshuricum;chemical constituent;structure elucidation |
| Author Name | Affiliation | E-mail | | DONG Yu-qi | Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China | | | YU Hua | Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China | | | WANG Chun-hua | Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | pharmwch@126.com | | LI Zheng | Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHU Yan | Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China | |
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| Abstract
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| [Objective] To investigate the chemical constituents from the alcohol fraction of the roots of Asarum heterotroprides var. Mandshuricum.[Methods] Column chromatographies of silica gel, preparative HPLC and Sephadex LH-20 are applied to isolate the chemical constituents. Pure compounds were elucidated by means of 1H NMR, 13C NMR and LC-MS.[Results] Fifteen compounds were isolated and identified as (1R, 2S, 5R, 6R)-5'-O-methylpluviatilol, methyl caffeate, (2E, 4E, 8E)-N-isobutyl-2, 4, 8-decatrienamide, cimicifugic acid, (1S, 4S, 5S)-5-isopropyl-2-methyl-2-cyclohxene-1, 4-diol, (±)-asarinol A, p-hydroxybenzaldehyde, 3-methoxy-4-hydroxybenzoic acid, 4-hydroxyphenethyl alcohol, p-hydroxycinnamic acid, β-sitosterol, L-asarinin, piperonylic acid, kakuol and 3, 4-dimethoxycinnamylic alcohol.[Conclusion] Compounds 1~10 were obtainted from Asarum heterotroprides var. mandshuricum for the first time. |
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