|
| Neuroprotective effects of Xinnao Shutong capsule on vascular dementia in rats |
| Hits 2062 Download times 1217 Received:October 05, 2017 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2018.01.18 |
| Key Words
Xinnao Shutong capsule;cascular dementia;Morris water maze;astrocyte;microglia;nerve |
| Author Name | Affiliation | E-mail | | Batnairamdal Chuluun | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Jinxin | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Ruilin | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LU Guoyan | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Hong | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHAI Lijuan | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Yue | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Shaoxia | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | wangshaoxia1@163.com | | HU Limin | Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | huliminth@126.com |
|
| Abstract
|
| [Objective] To investigate the neuroprotective effect of Xinnao Shutong capsules (XNST) on vascular dementia in rats.[Methods] Adult male Wistar rats[weight (300±20) g, eleven weeks old] were used in this experiment. The rats were randomly divided into control group, model, and two treatment (14, 56 mg/kg XNST) groups. The model of vascular dementia in rats was induced by bilateral common carotid artery ligation (BCCAL). Then throughout a period of two months. XNST was given intragastrically to rats. This was followed by rats' behaviors evaluation by Morris water maze method to obtain records of their performance regarding learning and memory. The changes of brain cell morphology were observed by Nissl stain. The expression IBA-1and GFAP of the hippocampus were measured with immunohistochemistry staining.[Results] XNST improved the ability of learning and memory in vascular dementia rats and prevented the loss of pyramidal cells on CA1 zone in the hippocampus. Moreover, the neuronal cell number was increased dramatically after XNST treatment in dose dependent manner. The number of pyramidal cells in XNST increased significantly than that in model group (P<0.01). XNST (56 mg/kg) can the activation of microglia(IBA-1)expression (P<0.01). XNST (56 mg/kg) could obviously inhibit the activation of astrocytes(GFAP)expression (P<0.01).[Conclusion] XNST can improve the learning and memory ability of vascular dementia rats, the underlying mechanism of the effects may be related to its action of preventing neuronal cell of hippocampus against ischemic injury inhibiting the astrocytes and microglia activation. |
|
|
|
|
|
|
|
