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| The efficacy and safety of Baofukang suppository for cervical high risk human papillomavirus (HR-HPV) infection:systematic review |
| Hits 2411 Download times 1976 Received:November 10, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.03.11 |
| Key Words
Baofukang suppository;cervical high risk human papillomavirus;systematic review;efficacy;safety |
| Author Name | Affiliation | E-mail | | JI Zhaochen | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Fengwen | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Lishuang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Mingyan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIN Xinyao | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHAO Hongjie | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Yue | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHENG Wenke | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zhengwk@tice.com.cn |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of Baofukang suppository in the treatment of high risk human cervical papillomavirus (HR-HPV).[Methods] The computer searches the Chinese knowledge database, the Wanfang database, the Weipu database, the SinoMed database, the PubMed database and the Cochrane database and the retrieval period is from the construction site to the March 2017. All randomized controlled trials (RCTs) of Baofukang treatment (HR-HPV) were collected. Two reviewers independently screened and extracted the data. The quality of the study methodology was evaluated using the Cochrane System Evaluation Manual Method, the dispute resolved through discussion.[Results] Thirteen RCTs were screened according to the inclusion criteria, and 1 424 patients were included in this study. Meta analysis showed that the Baofukang on the cervical HR-HPV negative rate, compared with the blank control (RR=2.90, 95%CI[1.92, 4.36]) (P<0.000 01), Baofukang and Western medicine Compare with Western medicine(RR=1.39, 95%CI[1.23, 1.57], P<0.000 01); on effective rate, Baofukang compare with Western medicine(RR=1.36,95%CI[1.11,1.66], P=0.003), Baofukang and Western medicine compare with Western medicine(RR=1.35,95%CI[1.16,1.57], P=0.000 1),the indicators are better than Western medicine; 2 cases of adverse events were reported in the group of Baofukang group (4 cases of adverse events reported in the control group).[Conclusion] The data analysis suggested that Baofukang was effective in the treatment of high risk human papillomavirus. Due to the relatively small number of research samples, the quality of the literature methodology is relatively low, the level of evidence has yet to be improved. |
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