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| Treatment of idiopathic pulmonary fibrosis by traditional Chinese medicine:a systematic review and Meta-analysis |
| Hits 2472 Download times 1543 Received:December 16, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.03.12 |
| Key Words
traditional Chinese medicine;idiopathic pulmonary fibrosis;systematic review;Meta-analysis |
| Author Name | Affiliation | | LIU Min | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Department of Respiratory Medicine, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | CHEN Minghu | Department of Respiratory Medicine, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | WEI Changlong | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | ZHAO Qiliang | Department of Respiratory Medicine, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To systematically evaluate the efficacy and safety of traditional Chinese medicine in treating patients with idiopathic pulmonary fibrosis (IPF).[Methods] Two researchers performed literature search, data extraction, quality assessment. The interventions of experiment group included Chinese herbal medicine and integrative medicine, and of control group included placebo and western medicine. Several outcome measures were assessed, such as FVC, TLC, DLCO, PaO2, 6MWD, SGRQ score, cough, dyspnea and adverse reaction rates. Meta-analysis was conducted by RevMan 5.3 software.[Results] A total of 17 Randomized controlled trials (RCTs) involving 1 113 patients were included. The meta-analysis resulted in a increase in FVC% pred, TLC% pred, DLCO% pred, PaO2. And there was a decrease in SGRQ score, cough score, adverse reaction rates. While no significant difference in 6MWD, dyspnea score compared to the control group. There were significant differences in FVC% pred, TLC% pred, DLCO% pred, PaO2 and SGRQ score in integrative medicine compared with Western medicine. While only one difference in FVC% pred in Chinese herbal medicine.[Conclusion] In the treatment of IPF for more than 6 months, the efficacy and safety of integrative medicine were significant, and of Chinese herbal medicine were inapparent, when compared with corticosteroids and antioxidant. However, due to the limitation of quality of included studies, this conclusion should be further confirmed by more evidence. |
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