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| Effect of Yiguanjian on expression of NF-κB mRNA and MMP-9 mRNA in placenta of preeclampsia model rat |
| Hits 1753 Download times 1237 Received:November 06, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.03.16 |
| Key Words
Yiguanjian;preeclampsia;NF-κB mRNA;MMP-9 mRNA |
| Author Name | Affiliation | E-mail | | LI Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CAO Baoli | Department of Obstetrics and Gynecology, Nankai Hospital of Tianjin, Tianjin 300100, China | xiaomh66@sina.com | | LIU Yun | Department of Obstetrics and Gynecology, Nankai Hospital of Tianjin, Tianjin 300100, China | |
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| Abstract
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| [Objective] To explore of the effect of Yiguanjian on expression of NF-κB mRNA and MMP-9 mRNA in placenta of preeclampsia model rat.[Methods] The preeclampsia rat model was established and intragastric administration of traditional Chinese medicine Yiguanjian. The changes of blood pressure and 24 h urine protein of rats were monitored before and after dosing. The PCR method to measure the expression of NF-κB mRNA and MMP-9 mRNA in placenta of pregnant rats.[Results] 1) The expression of NF-κB mRNA in model control group and Yiguanjian treat group was higher compared with the normal group, with statistical significance (P<0.05), and the expression in Yiguanjian treat group was lower compared with model contonl group, with statistical significance (P<0.05). 2) The expression of MMP-9 mRNA in model control group and Yiguanjian treat group was lower compared with the normal group, with statistical significance (P<0.05), and the expression in Yiguanjian treat group was higher compared with model control group, with statistical significance (P<0.05).[Conclusion] Yiguanjian treatments preeclampsia model rat by reducing the expression of NF-k-B mRNA and rising the expression of MMP-9 mRNA in placenta. |
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