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| Analysis for the neurobiological mechanism of tonifying kidney treating female climacteric depression |
| Hits 1741 Download times 1311 Received:November 20, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.03.21 |
| Key Words
female climacteric depression;estrogen;neurogenesis;booting kidney method |
| Author Name | Affiliation | E-mail | | XU Hongdan | Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 154040, China
College of Jiamusi, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China | | | ZHANG Bo | Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 154040, China | | | LIU Xiumin | Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 154040, China | | | HUANG Shuming | Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 154040, China | huangsm1958@163.com |
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| Abstract
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| Female climacteric depression (FCD) is a common disease in menopausal women, its incidence is high, the harm is great, and there is still no ideal treatment. "Hippocampal neurogenesis disorder" is thought to be the major pathogenesis, which could be caused by many kinds of factors. The diminished brain protection of estrogen related to decreased estrogen level could lead to imparment of hippocampal neurogenesis directly and indirectly. Thus it can be seen that the incidence of FCD is closely related to the dysfunction of hippocampal neurogenesis caused by low estrogen and the functional disorder of hypothalamic pituitary adrenal (HPA) axis in climacteric women. Traditional Chinese Medicine believes that "kidney is communicated to the brain", "kidney houses essence, essence transforms into marrow, and brain is the sea of marrow." Boosting kidney can help generate marrow and fortify the brain. |
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