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| Evidence and evaluation of Xuesaitong injection in treating stroke |
| Hits 2762 Download times 2213 Received:December 20, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.04.12 |
| Key Words
Xuesaitong injection;stroke;systematic evaluation and Meta-analysis;AMSTAR;evidence |
| Author Name | Affiliation | E-mail | | ZHANG Mingyan | Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Fengwen | Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Yue | Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Junhua | Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zjhtcm@foxmail.com |
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| Abstract
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| [Objective] To evaluate evidence from systematic evaluation or Meta-analysis of xuesaitong injection in the treatment of stroke. [Methods] CNKI, Sinomed, Wanfang, PubMed, Cochrane library and Embase to collect SRs of xuesaitong injection in treating stroke were searched. The methodology quality was evaluated by the AMSTAR scale. [Results] A total of 9 SRs involving 7 outcomes were included. Compared with other drug or conventional therapy, total clinical effect of Xuesaitong injection treating stroke was better. There were 3 studies showed advantages in improving neurologic impairment degree after stroke. One study showed it can decrease the aggravation rate and death rate obviously, but quality of evidence was low. There were 3 high-quality (>80%) items:inclusion criteria, data resources and the scientific quality of the included studies. There were 3 items with moderate quality (50%~80%):exclusion criteria, the characteristics of the included studies and publication bias; the remaining 12 items with poor quality (<50%). Among them, the quality of 3 items was very low, such as, pre-determined research objectives, grey literature and a list of studies. [Conclusion] The current published SRs suggest xuesaitong injection appears to be safe and effective to improve neurological deficits for stroke treatment in general. However, it lacks high evidence. Further well-designed RCTs are needed. |
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