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| Effects of allicin on hemodynamics and hemorheology in septic shock rats |
| Hits 1503 Download times 1261 Received:January 03, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.04.15 |
| Key Words
allicin;infection;shock;hemodynamics;hemorheology |
| Author Name | Affiliation | | ZHANG Kun | Department of Emergency, Wu'an First People's Hospital, Wu'an 056300, China |
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| Abstract
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| [Objective] To study the effect of allicin on hemodynamics and hemorheology in septic shock rats and explore the protective mechanism of allicin on septic shock. [Methods] The rat model of septic shock was reproduced by tail vein injection of lipopolysaccharide (5 mg/kg) and were randomly divided into model group, allicin (3, 6, 12, 24 mg/kg) groups (n=20); and set normal control group(n=20). The drugs were administered by intraperitoneal injection. 24 h later, the indexes of hemodynamics, hemorrheology and blood lipid were determined. [Results] The index of hemodynamics were significantly improved in allicin (6, 12, 24 mg/kg) groups, including incresing the SAP, DAP, MAP, LVSP (P<0.05 or P<0.01), increasing the lv+dp/dtmax and decreasing t-dp/dtmax; the index of hemorrheolog were significantly improved, including reducing whole blood viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte degeneration index, erythrocyte rigidity index (P<0.05 or P<0.01); the indexes of blood lipid were significantly improved, including decresing the content of TG, TC, LDL-C and increasing the content of HDL-C (P<0.05 or P<0.01). [Conclusion] Allicin has the effect of improving hemodynamics and hemorheology in septic shock rats. |
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