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| Study on compatibility stability of Xueshuantong for injection with different common solvents |
| Hits 1559 Download times 1408 Received:August 28, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.04.18 |
| Key Words
Xueshuantong for injection;solvent;compatibility |
| Author Name | Affiliation | E-mail | | ZHANG Ping | Pharmacy Department, The 452 Hospital of the Chinese People's liberation army, Chengdu 610065, China | | | HUANG Rong | Pharmacy Department, The 452 Hospital of the Chinese People's liberation army, Chengdu 610065, China | 364252494@qq.com |
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| Abstract
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| [Objective] To investigate the stability of compatibility of Xueshuantong for injection with 5 kinds of common solvents and optimize the best solvent compatibility program to provide basis for promoting clinical rational and safe drug use. [Methods] According to the prescription of drugs, the injection of thrombosis with 5 kinds of commonly used solvents compatibility, regular inspection compatibility appearance, pH and insoluble particles. [Results] There was no obvious change in the appearance and pH value of Xueshuantong for injection after mixing with five kinds of commonly used different solvents. However, the insoluble particles increased with the increase of compatibility time, and the number of insoluble particles ≥ 10 μm exceeded after 6 h 2015 edition of Chinese Pharmacopoeia limits, and with 0.9% sodium chloride injection with 4 h ≥ 10 μm and ≥ 25 μm insoluble particles have exceeded the 2015 edition of the Chinese Pharmacopoeia limits. [Conclusion] The optimal compatibility of injection of Xueshuantong for injection is 10% glucose injection, followed by 5% glucose injection and glucose and sodium chloride injection, and the solution after compatibility should be used within 6 h, If used in patients with diabetes, need 0.9% sodium chloride injection vehicle preparation, the compatibility of the solution should be used within 4 h. |
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