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| Effects of artemisinin combined with erlotinib on lung cancer cells |
| Hits 1543 Download times 1270 Received:December 18, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.05.17 |
| Key Words
artemisinin;erlotinib;apoptosis;cell activity |
| Author Name | Affiliation | | ZHAO Fucheng | Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | HAN Yanru | Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | JIA Kui | Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | LIU Caili | Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | LIU Zhenzhou | Department of Integrated TCM & Western Medicine, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China |
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| Abstract
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| [Objective] To investigate the effect of artemisinin combined with erlotinib on the activity and apoptosis of lung cancer cells.[Methods] The activity of A549 lung cancer cells treated with artemisinin and erlotinib at different concentrations was determined by CCK-8. The apoptosis of A549 lung cancer cells was detected by flow cytometry. The effects of artemisinin and erlotinib were investigated by intratumoral injection mouse tumor.[Results] The cell viability of A549 lung cancer cells was decreased by 91% when combining artemisinin with erlotinib, and the optimal concentration was artemisinin at 10 μg/mL and erlotinib at 10 μg/mL. The apoptotic rate of the cells treated with artemisinin and erlotinib at optimal concentrations was up to 90%, which was signifcantly higher than that of the cells treated with artemisinin or erlotinib alone at the same concentration. The tumor volume of intratumoral injection of artemisinin and erlotinib was significantly smaller in mice.[Conclusion] Artemisinin combined with erlotinib can reduce lung cancer cell activity, induced apoptosis. In vivo can also effectively reduce the tumor volume. |
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