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| Research progress of AMPK in protecting vascular function |
| Hits 2187 Download times 2227 Received:December 29, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.05.18 |
| Key Words
AMPK;vascular function;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | ZHANG Yang | Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China | | | WANG Li | Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China | | | CAO Aili | Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China | | | CHEN Junliang | Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China | | | PENG Wen | Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China | | | WANG Hao | Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China | wang402hao@163.com |
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| Abstract
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| Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine protein kinase and sensor of cellular energy status,which involved in the regulation of cellular and whole organ metabolism. Activation of AMPK has a number of potentially beneficial antiatherosclerotic effects including reducing adhesion of inflammatory cells to the blood vessel endothelium, reducing lipid accumulation and the proliferation of inflammatory cells caused by oxidised lipids, stimulation of gene expression responsible for cellular antioxidant defenses and stimulation of enzymes responsible for nitric oxide formation. In addition to drugs commonly used in cardiovascular and metabolic disease, such as statins, metformin and the TZDs, many of the TCM also involve the activation of AMPK. In general, the activation of AMPK is closely related to the maintenance of vascular health. This paper reviews the research progress of the role and mechanism of AMPK in the protection of vascular function. |
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