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| Observation on the inhibition of inflammatory cytokines and the intervention of myocardial fibrosis by Dingjifang recipe |
| Hits 1684 Download times 1236 Received:April 03, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.06.03 |
| Key Words
paroxysmal atrial fibrillation;inflammatory;cytokines myocardial fibrosis;Dingjifang recipe |
| Author Name | Affiliation | E-mail | | HUANG Yao | Chinese Medicine Internal Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | ZHANG Zhenxian | Chinese Medicine Internal Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | zhenxianzhang@hotmail.com | | CHEN Ruohong | Chinese Medicine Internal Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | DING Yueyi | Chinese Medicine Internal Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | CHEN min | Chinese Medicine Internal Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | |
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| Abstract
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| [Objective] To observe the inhibition of inflammatory cytokines and the intervention of myocardial fibrosis in qi and yin deficiency synclrome patients with paroxysmal atrial fibrillation between Dingjifang recipe group and Western medicine group.[Methods] The 60 patients, according to the inclusion criteria, randomly divided into for treatment group and control group, compared the difference between two groups before and after treatment, including attack frequency, traditional Chinese medicine symptoms, high-sensitivity CRP (hsCRP), interleukin 6 (IL-6) and tumor necrosis factor-α(TNF-α), left atrial diameter, left ventricular ejection fraction (LVEF) and left ventricular short axis fractional shortening (FS).[Results] After treatment, the clinical symptom improvement rate of treatment recipe group was higher than that of control group. The difference was statistically significant (P<0.01). The serum hsCRP and IL-6 of patients in two groups were significantly lower than before treatment (P<0.05), and the serum levels of hsCRP and IL-6 in treatment group were lower than in the control group (P<0.05). Patients followed up for six months, LVEF, FS values in two groups were higher than that before treatment(P<0.05), and the LVEF increased more significantly in treatment group than control group (P<0.05), the left atrial diameter of treatment group was significantly decreased after treatment (P<0.05).[Conclusion] Dingjifang recipe can effectively inhibit the over expression of inflammatory factors and improve myocardial fibrosis and ventricular remodeling. |
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