|
| Effect on serum inflammatory factors,endothelial function and cardiovascular events of Xuefu Zhuyu decoction in coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution |
| Hits 15373 Download times 1329 Received:March 01, 2018 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2018.06.04 |
| Key Words
Xuefu Zhuyu decoction;coronary heart disease;hyperlipidemia;blood stasis constitution;inflammatory factor;endothelial function;cardiovascular event |
| Author Name | Affiliation | | LIU Yanjun | Vasculocardiology Deparment, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | | LI Quan | Vasculocardiology Deparment, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | | GUO Xiaomei | Vasculocardiology Deparment, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China |
|
| Abstract
|
| [Objective] To observe the effect on serum inflammatory factors,endothelial function and cardiovascular events of Xuefu Zhuyu decoction in coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution.[Methods] The 125 cases of coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution were randomly divided into the observation group (64cases)and the control group(61 cases). The control group was given conventional therapy, and the observation group was given Xuefu Zhuyu decoction for 2 months based on conventional therapy. For 6 months, the changes of serum inflammatory factors, endothelial function and cardiovascular events were observed between the two groups.[Results] 1)There was significantly difference of IL-1β,IL-18,hs-CRP,TNF-α in these two groups (P<0.05). All indexes of the two groups were showed a declining trend over time (P<0.05), the changed amplitude in observation group was higher than the control group (P<0.05). 2)There was significantly difference of NO,6Keto-PGF-1α, ET-1,TAXB2 in these two groups (P<0.05), the two groups of NO,6-Keto-PGF-1a were showed a rising trend over time and ET-1,TAXB2 were showed a declining trend over time (P<0.05), the changed amplitude in observation group was higher than the control group (P<0.05). 3) In the observation group, the total incidence rate cardiovascular events group was 7.81%, and that of the control group was 22.95%, with significant difference (P<0.05).[Conclusion] Xuefu Zhuyu decoction can inhibit inflammation, protect endothelial function and reduce the occurrence of cardiovascular events in coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution. |
|
|
|
|
|
|
|
