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| A Meta-analysis of effectiveness and safety about Mahuang Xixin Fuzi decoction in treating bradycardia arrhythmia |
| Hits 1982 Download times 1583 Received:March 05, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.06.09 |
| Key Words
Mahuang Xixin Fuzi decoction;bradycardia arrhythmia;RCTs;Meta-analysis;effectiveness;safety |
| Author Name | Affiliation | E-mail | | DENG Yafang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XU Qiang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | HUANG Yuhong | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | WANG Baohe | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | wbh3423@sina.com |
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| Abstract
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| [Objective] A systematic review of the effectiveness and safety about Mahuang Xixin Fuzi decoction treating bradycardia arrhythmia.[Methods] By using the computer retrieval and manual search,we can retrieve clinical randomized controlled trials about Mahuang Xixin Fuzi decoction treating bradycardia arrhythmia from 2000 Jan. to 2017 Apr.. According to the Inclusion criteria and exclusion criteria, we screen literature and extract data, and data analyzed by Revman 5.3.[Results] Totally 19 RCTs were included with 1 530 cases. The data showed that Mahuang Xixin Fuzi decoction group can improve the effectiveness of patients[RR=1.30, 95%CI (1.23, 1.38), P<0.00001]. Comparison of basal heart rate after treatment:compared with the control group, the treatment group has statistical difference[MD7.87, 95%CI (6.47, 9.26), P<0.000 01]. Comparison of the slowest heart rate after treatment, compared with the control group, the treatment group has statistical difference[MD 6.45, 95%CI (4.72,8.18), P<0.000 01]. Comparison of mean heart rate after treatment, compared with the control group, the treatment group has statistical difference[MD7.20, 95%CI (6.23, 8.16), P<0.000 01]. Comparison of resting heart rate after treatment, compared with the control group, the treatment group has statistical difference,[MD 8.03, 95%CI (6.52, 9.54), P<0.000 01]. Comparison of TCM syndromes improvement after treatment, compared with the control group, compared with the control group, the treatment group has statistical difference[RR=1.47, 95%CI (0.94, 2.30), P<0.10]. The adverse events between treatment group and control group did not occur.[Conclusion] Mahuang Xixin Fuzi decoction has certain effects on the clinical efficacy and heart rate in the treatment of bradycardia arrhythmia, and also has certain safety. |
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