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| Effects of Suxiao Jiuxin pill on the blood lipid, the pathologic change of arteria aorta and the expression of ABCA1 of arteria aorta in rats of atherosclerosis |
| Hits 1461 Download times 1411 Received:December 25, 2017 |
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| DOI
10.11656/j.issn.1672-1519.2018.06.13 |
| Key Words
atherosclerosis;Suxiao Jiuxin pill;blood fat;pathologic change;ABCA1 |
| Author Name | Affiliation | | WANG Shasha | Diabetes Department, Tianjin Nankai District traditional Chinese Medicine Hospital, Tianjin 300102, China | | QU Zhuqiu | Traditional Chinese Medicine Department, Tianjin Medical University General Hospital, Tianjin 300052, China |
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| Abstract
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| [Objective] To observe the effects of Suxiao Jiuxin pills on the blood lipid and the pathologic change in rat of atherosclerosis.[Methods] Experimental atherosclerosis in rats was produced by feeding with atherogenic-diet and vitaminD3 administration. The 60 male mature Sprague-Dawlay rats were divided into 6 groups randomly and equally:normal group; AS model group; SXL group; SXM group; SXH group and Astorvastatin group. SX or Astorvastatin was given by gavage from the beginning of the first week to the end of the experiment. At the same time, normal saline was given to the rats of normal group and model group with the same volume and the same way. After 12 weeks, the contents of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in serum of rats were determined. The pathologic change of artery was observed.[Results] In the model group, TC、TG、LDL and HDL were increased significantly compared with the normal group (P<0.05). The levels of TC, TG and LDL were declined and the level of HDL was increased evidently in the SXM, SXH groups(P<0.05). Compared with the model group, the pathological changes of aortic ultra structure alleviated obviously in the SXM, SXH and ATO groups. Compared with the model group, the expression of ABCA1 of aortic was not influenced in the SXL, SXM and ATO group(P>0.05), while, it was increased in the SXH group(P<0.05).[Conclusion] Suxiao Jiuxin pills has obvious effect on decreasing the serum levels of TC, TG, LDL, and increasing the serum of HDL in AS rats. Pathological changes of aorta shows Suxiao Jiuxin pills can ameliorate the atherosclerotic changes. Suxiao Jiuxin pills can increase the expression of ABCA1of aortic. |
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