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| Systematic review on effect and safety of Sanjiu Weitai for chronic gastritis |
| Hits 6352 Download times 1739 Received:March 13, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.07.11 |
| Key Words
Sanjiu Weitai;chronic gastritis;effect;safety;systematic review |
| Author Name | Affiliation | E-mail | | ZOU Jiahan | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Fengwen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Xuemei | Baokang Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lxmtcm@126.com |
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| Abstract
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| [Objective] In this study, we evaluated the efficacy and safety of Sanjiu Weitai for chronic gastritis.[Methods] We searched CNKI, Wanfang Data, SinoMed and PubMed (before Sep 2016), and collected relevant randomized controlled trials (RCTs). Two authors independently performed screening the literature and data extraction, the quality of included references was evaluated according to criteria recommended by Cochrane Handbook and the disputes were resolved through discussion.[Results] A total of 673 articles were retrieved and 8 RCTs, including 614 patients were enrolled in this study according to the inclusion criteria. Because of a significant clinical heterogeneity among these studies, we finally performed descriptive analysis instead of data analysis. Sanjiu Weitai showed comparative efficacy in alleviating clinical symptoms including abdominal pain, belching, acid regurgitation and etc., compared to omeprazole, teprenone, bismuth potassium citrate granule, marzulene-S and antibiotics. In the clearance rate of Hp, the efficacy of Sanjiu Weitai is not so good as bismuth potassium citrate granule, but in restoring intestinal metaplasia and gastric mucosal hyperplasia, Sanjiu Weitai has a comparative efficacy with marzulene-S. When concerned with safety, no obvious adverse reactions were reported in the group of Sanjiu Weitai.[Conclusion] Sanjiu Weitai was effective for Chronic Gastritis. However, due to the limited number of eligible RCTs, significant heterogeneity and poor methodological quality, the advantages of Sanjiu Weitai in treating chronic gastritis need high quality RCTs to prove. |
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