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| Correlation analysis of traditional Chinese medicine syndromes for different liver fibrosis in chronic hepatitis C |
| Hits 1495 Download times 1335 Received:March 17, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.08.05 |
| Key Words
chronic hepatitis C;syndrome of traditional Chinese medicine;liver stiffness;correlation analysis |
| Author Name | Affiliation | | ZHANG Hong | Prevention Department, Tianjin Second People Hospital, Tianjin 300192, China | | TAO Sen | Hepatology Department, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | DUAN Yili | Prevention Department, Tianjin Second People Hospital, Tianjin 300192, China | | CAO Wukui | Prevention Department, Tianjin Second People Hospital, Tianjin 300192, China | | WANG Hongwu | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the traits of syndrome and key factors of traditional Chinese medicine (TCM) in the patients with chronic hepatitis C(CHC)whose fibrosis were different.[Methods] The 452 patients who have been diagnosed clinically chronic hepatitis C have been done syndrome differentiation of TCM, at the same time the patients have been examined to LSM by transient elastography which have been evaluated the extent of liver fibrosis. All of patients have been divided into three groups by LSM 7.3-14.6Kpa. The three groups respectively were no or mild fibrosis group which LSM were inferior to 7.3 kPa, the significant fibrosis group which LSM were between 7.3~14.6Ka and the severe fibrosis group which LSM were equal or greater than 14.6 kPa. The t test or variance analysis has been exerted in comparison of measurement data. The Chi-square test has been applied comparison of enumeration data. The symptoms and signs were analyzed by clustering method.[Results] There were 390 patients of CHC who were brought into the study, including 244 patients whose liver stiffness measurements are inferior to 7.3 kPa. In addition, the LSM of 75 patients were among 7.3~14.6 kPa, the LSM of 71 patients were equal or greater than 14.6 kPa. The TCM syndrome elements which LSM was below 7.3 kPa in CHC were mainly liver stagnation spleen deficiency. The syndrome element which LSM were within the scope of 7.3~14.6 kPa were liver stagnation and spleen deficiency in addition to blood stasis and kidney asthenia. The syndrome element which LSM reaching or exceeding 14.6 kPa was principally qi deficiency blood stasis, hepatic and renal Yin deficiency.[Conclusion] The TCM syndrome key factors patients with CHC whose liver fibrosis were mild were mainly liver stagnation spleen deficiency. The TCM syndrome key factors patients with CHC whose liver fibrosis were advanced were characterized by qi deficiency, blood stasis, hepatic and renal Yin deficiency. |
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