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| Effect of Danqi Piantan capsule on cognitive function of rats with chronic cerebral ischemia |
| Hits 1222 Download times 1042 Received:June 05, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.08.18 |
| Key Words
Danqi Piantan capsule;chronic cerebral ischemia;cognitive function |
| Author Name | Affiliation | E-mail | | LIU Jianping | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Jinbo | Center for Health Food Evaluation China Food and Drug Administration, Beijing 100070, China | | | WANG Yang | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | dayang810025@163.com | | CHEN Tao | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To explore the effect of Danqi Piantan capsules on cognitive function of rats with chronic cerebral ischemia.[Methods] The 40 rats were randomly divided into model group, sham operation group (given sodium carboxymethyl cellulose sodium solution), Danqi Piantan capsules (43.2 mg/mL). The ischemia model of four artery ligation rats was prepared, and the drug was given at 2 weeks after making the model, and the period of the drug delivery was 1 months. The effects of Morris water maze and fatigue tester on balance and learning and memory ability of rats with ischemic model of forebrain were investigated.[Results] Compared with the model group, Danqi rats escape latency were significantly reduced (P<0.05), was significantly higher in the platform (P<0.01), residence times across the platform significantly increased (P<0.01), the number of falling from the rotarod was significantly reduced (P<0.01), increased significantly in turn on the bar long residence time (P<0.05).[Conclusion] Danqi Piantan capsules can improve the cognitive function of chronic cerebral ischemia rats induced by four artery ligation. |
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