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| Research progress of prevention and treatment of MIRI by tranditional Chinese medicine based on NF-κB signaling pathway |
| Hits 1284 Download times 1005 Received:May 05, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.09.20 |
| Key Words
myocardial ischemia reperfusion injury;NF-κB;traditional Chinese medicine;research progress |
| Author Name | Affiliation | | ZHAO Guifeng | Department of Cardiovascular, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | ZHANG Yunjiao | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | TANG Gengyi | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| Myocardial ischemia. reperfusion injury (MIRI) is a phenomenon that the myocardial injury aggravates after the restoration of blood perfusion. With the continuous development of thrombolysis, interventional and cardiac surgical techniques, MIRI is significantly increased, affecting the clinical efficacy of reperfusion therapy. At present, it is thought that the mechanism of MIRI is related to the damage of peroxide, calcium overload and inflammatory reaction, among which, NF-κB acts as an important transcription factor and regulates the transcription of related factors guide the progress of MIRI. In recent years, traditional Chinese medicine based on the NF-κB signaling pathway to prevent and cure MIRI research gradually increased. This article summarizes the research status of traditional Chinese medicine monomers and effective components, compound, Chinese patent medicine, traditional Chinese medicine injection and acupuncture therapy. |
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