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| Study on preparation technology of Aifu Nuangong soft capsule |
| Hits 1396 Download times 1066 Received:August 04, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.10.17 |
| Key Words
Aifu Nuangong soft capsule;preparation technology;response surface methodology |
| Author Name | Affiliation | E-mail | | WANG Jian | Henan food and Drug Inspection Institute, Zhengzhou 450018, China | | | ZHANG Zhuangli | Henan Academy of Medical Sciences, Zhengzhou 450052, China | | | YANG Haiyan | Henan food and Drug Inspection Institute, Zhengzhou 450018, China | | | LI Fengchun | Henan food and Drug Inspection Institute, Zhengzhou 450018, China | | | ZHU Xiaoxiao | Nanjing University of Chinese Medicine, Nanjing 210023, China | | | GU Ningning | Nanjing University of Chinese Medicine, Nanjing 210023, China | | | WU Juan | Nanjing University of Chinese Medicine, Nanjing 210023, China | | | ZHANG Xingde | Nanjing University of Chinese Medicine, Nanjing 210023, China | xingde2293@126.com |
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| Abstract
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| [Objective] To optimize the preparation of AIfu Nuangong soft capsule.[Methods] On the basis of single factor experiment,with fluidity, uniformity and settlement volume ratio as index, the optimal process conditions were determined by Box-Behnken design as follows; the quality of capsule shells depending on the adhesive toughness and viscosity.[Results] Soybean oil is a good dispersing medium, and the ratio between drug soybean oil and beeswax is 1:2.2:6.25% can make sure the suspension system is best, and the best prescription of capsule shells was gelatin:glycerol:water=1:0.4:1. besides when the temperature of box is between 50~60℃,the temperature of the spray body is 35~37℃, and the cooling temperature is 16~18℃, the capsule is best.[Conclusion] The preparation process parameters are reasonable and the preparation is stable. |
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