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| Advances in studies on chondrogenic and osteogenic differentiation of bone morrow mesenchymal stem cells induced by Chinese materia medica |
| Hits 1711 Download times 1297 Received:June 23, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.10.19 |
| Key Words
Chinese materia medica;bone marrow mesenchymal stem cells;chondrogenic differentiation;osteogenic differentiation |
| Author Name | Affiliation | E-mail | | PAN Huixin | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CUI Yuanlu | Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | ylcui@tjutcm.edu.cn |
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| Abstract
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| Bone marrow mesenchymal stem cells (BMSCs) are characterized by strong self-renewal ability, multi-directional differentiation potential, low immunogenicity and good-homing ability. Thus, BMSCs are ideal seed cell for bone and cartilage tissue engineering. At present, BMSCs differentiation induced by cytokines cannot be widely applied in clinical practice due to the expensiveness and safety issues. Recent studies have shown that Chinese materia medica and its active ingredients can induce the differentiation of BMSCs, and have similar physiological activity as cytokines. In this paper, we aimed to review the research advances of BMSCs chondrogenesis and osteogenesis induced by Chinese materia medica, and to provide references for the prevention and/or treatment of orthopedic diseases. |
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