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| Clinical and biochemical basic research of the phlegm and blood stasis syndrome of coronary heart disease stable angina treated with Danlou Tablet |
| Hits 1332 Download times 1036 Received:July 07, 2018 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2018.11.03 |
| Key Words
coronary heart disease stable angina pectoris;phlegm and blood stasis syndrome;clinical biochemistry;multi-centers;refine |
| Author Name | Affiliation | E-mail | | XU Yilan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Shan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DENG Bing | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | MAO Meijiao | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | DU Tinghai | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China | | | LI Bin | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China | | | YANG Baoping | Gansu Provincial Hospital of Traditional Chinese medicine, Lanzhou 730699, China | | | YU Yan | Gansu Provincial Hospital of Traditional Chinese medicine, Lanzhou 730699, China | | | ZHANG Hong | Tianjin Nankai Hospital, Tianjin 300100, China | | | ZHANG Shishu | Tianjin Nankai Hospital, Tianjin 300100, China | | | MAO Jingyuan | The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Xianliang | The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XU Qiang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | ZHANG Lei | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | SONG Guangming | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | TIAN Li | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | WANG Li | Tianjin Second People Hospital, Tianjin 300192, China | | | YAN Dandan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Shuming | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | PAN Ye | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CAI Xuemeng | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Shuo | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Xiaofeng | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | AI Le | Tianjin Zhongxin Pharmaceutical Group Limited by Share Ltd Lerentang Pharmaceutical Factory, Tianjin 300112, China | | | HU Jingqing | Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China | | | BIAN Yuhong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | bianyuhong_2012@163.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | ycq-4@163.com |
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| Abstract
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| [Objective] To explore the phlegm and blood stasis syndrome of coronary heart disease treated with Danlou Tablets by clinical biochemical basis through comparing the strict screening of coronary heart disease stable angina mutually by phlegm and blood stasis clinical and biochemical indexes of patients and healthy people with the multicenter and fineness clinical research.[Methods] From the seven clinical research centers, 82 cases were selected to the observation, with 4 cases deletion, 38 patients of coronary heart disease with phlegm and blood stasis syndrome, on the basis of conventional Western medicine therapy and Danlou tablet treatment, and 40 healthy people were not involved in the treatment. Endothelial cell injury was detected, lipid metabolism, adhesion molecules and inflammatory mediators, metalloproteinases, homocysteine and blood coagulation function 7 class 28 indicators, was detected in patients with coronary heart disease (CHD) level 0, 8, 12 weeks, healthy people group testing week 0 level.[Results] The phlegm and blood stasis syndrome of coronary heart disease has correlation with HDL-C, MMP9 and APTT. The treatment of trichosanthes decoction can reduce the level of inflammatory factors and improve the vascular endothelial injury.[Conclusion] The mechanism of Danlou Tablets on treating stable angina pectoris of coronary heart disease with phlegm and blood stasis syndrome is related to the regulation of endothelial injury, lipid metabolism, inflammatory factors, coagulation function and metalloproteinase. It can provide reference for further research. |
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