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| Meta-analysis of randomized controlled trials of traditional Chinese medicine in the treatment of Decline in ovarian reserve |
| Hits 1508 Download times 1090 Received:June 22, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.11.12 |
| Key Words
traditonal Chinese medicine;decline in ovarine reserve;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | ZHANG Xiaofen | Beijing University of Chinese Medicine, Beijing 100029, China | | | LI Yunbo | The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | cindylee100001@163.com | | PAN Xue | Beijing University of Chinese Medicine, Beijing 100029, China | | | XIAO Jinhe | Beijing University of Chinese Medicine, Beijing 100029, China | |
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| Abstract
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| [Objective] To systematically evaluate the clinical efficacy of traditional Chinese medicine in the treatment of decline in ovarian reserve.[Methods] Databases were searched in the treatment of decline in ovarian reserve. It includes many treatments of decline in ovarian reserve for clinical randomized controlled trials of the research object, or randomized controlled clinical trials in name. Risk of bias evalution tools of Cochrane were adopted to cinduct quality evalution. Meta-analysis on outcome indicator was performed by RevMan Version 5.1 Software.[Results] Finally, 18 clinical randomized controlled trials were included. These trials were divided into two groups:tradition Chinese medicine decoction or granule to Western medicine hormone and tradition Chinese medicine decoction or granule combined and Western medicine hormone to western medicine hormone. Besides, each group was divided as different subgroup analysis by syndrome differention and treatment. Traditional Chinese medicine or combined with Western medicine hormone had remarkable advantages over Western medicine hormone on reducing FSH and improving the Chinese medicine symptom curative effect; the advantages on reducing FSH/LH and increasing AMH were not clear. The trails showed less adverse reactions and follow-up reports, which reduced the quality of the literature demonstration. However, limited by the poor quantity of studies, these conclusions remain to be examined by more center, more sample and high-quality studies.[Conclusion] The meta-analysis showed that Chinese herbal decoction or granules (combined with western medicine hormones) had a certain effect in improving ovarian reserve dysfunction. Of course, the quality of the literature included in this study was not very high. Therefore, a large number of high-quality randomized controlled trials were needed to verify it and improve its scientificity and objectivity. |
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