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| Clinical observation of combination therapy of traditional Chinese medicine Xinshu mixture and Sertraline Hydrochloride for the treatment of depression |
| Hits 1417 Download times 1028 Received:August 20, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.12.05 |
| Key Words
Xinshu mixture;Sertraline Hydrochloride;combination therapy;depression |
| Author Name | Affiliation | | CHENG Hongyan | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China |
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| Abstract
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| [Objective] To study the clinical observation of combination therapy of traditional Chinese medicine Xinshu mixture and Sertraline Hydrochloride for the treatment of depression.[Methods] The 100 patients were randomly divided into observation group and control group and 50 cases for each. The observation group was given Xinshu mixture combined Sertraline Hydrochloride, and the control group received only Sertraline Hydrochloride. Patients' HAMD score, serum BDNF levels and situation of untoward reaction were recorded and analyzed before and after treatment.[Results] 1) After 8 weeks and 12 weeks treatment, HAMD score of observation group was (10.52±1.83) and (6.91±1.04), it was better than the control group (18.72±2.27) and (11.58±1.74), and the difference was statistically significant (P<0.05). 2) The serum BDNF level of the observation group was (1 288.86 ±468.40) pg/mL, which was better than the control group (1 183.27±362.52) pg/mL after treatment, and the difference was significant (P<0.05). 3) As for the overall therapeutically effectiveness, observation group reached 84.0%, which was much higher than the control group 70.0%, and the difference was statistically significant (P<0.05). 4) The incidence rate of drowsiness, gastrointestinal discomfort, dizziness and dry mouth in observation group was lower than the control group, and the difference was statistically significant (P<0.05).[Conclusion] Xinshu mixetru combined with Sertraline Hydrochloride was much more effective and has less incidentce rate of side effects, and it is worth further clinical research and promotion. |
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