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| Analysis of status on clinical research of integrative Chinese and Western medicine treatments after percutaneous coronary intervention |
| Hits 1445 Download times 1124 Received:July 25, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.12.12 |
| Key Words
after PCI;integrative medicine;antiplatelet agents;activating blood and removing blood stasis |
| Author Name | Affiliation | E-mail | | ZHAO Hongjie | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Liping | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Fengwen | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Mingyan | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Lishuang | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FENG Rui | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Junhua | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zjhtcm@foxmail.com |
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| Abstract
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| [Objective] To investigate the status of clinical research on integrative medicine treatments after percutaneous coronary intervention(PCI).[Methods] Seven databases including CNKI, WANFANG Data, Sinomed, Pubmed, Embase, Web of science, Cochrane Library were retrieved to collect randomized controlled trials (RCTs) about integrative medicine treatments for patients after PCI. Two reviewers independently screened literature and extracted data according to the inclusion and exclusion criteria. Disagreements were resolved by discussion.[Results] A total of 740 RCTs were included for analysis. Antiplatelet agents were most commonly used in the analysis of western medicines. The 59.2% of the studies used dual antiplatelet therapy (of which 8.4% used only dual antiplatelets, 50.8% used dual antiplatelets combined with other western drugs, including anticoagulants, statins, beta-blockers, nitrates, angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor antagonists, calcium antagonists, etc.). The 7.3% of the studies used single antiplatelet combined with other western medicines. The 4.7% did not mention antiplatelet therapy. 28.8% of the studies mentioned the use of conventional western medicine, but the specific drug names were not reported. Chinese patent medicine and decoction were most commonly used in the analysis of traditional Chinese medicine. The 39.9% of the studies used oral Chinese patent medicine, including 100 varieties. The top 3 were Tongxinluo capsule (8.1%), compound salvia miltiorrhiza dropping pills (3.1%) and Tongguan capsule (1.6%). The 27% of the studies used traditional Chinese medicine injections, including 31 varieties. The top 3 were Danhong injection (6.6%), Salvia miltiorrhiza polysalinate injection (3.4%) and Shuxuetong injection (2.7%), which were all drugs for activating blood and removing blood stasis. The 33.9% of the studies used decoction, including self-made decoction (25.7%) and classical decoction (8.2%). The 0.4% of the studies used single herb, including 3 varieties which were Salvia miltiorrhiza and Saint John. Grass and ginseng. There were 454 combinations between Chinsese and western drug. The top 3 included self-made decoction combined with conventional western medicine(8.0%), Tongxinluo capsule combined with conventional western medicine(2.4%), self-made decoction combined with dual antiplatelet therapy and statins.[Conclusion] There are numerous kinds and quantities of Chinese and Western medicine in integrative medicine studies after PCI. Dual antiplatelet therapies and drugs for activating blood and removing blood stasis were mainly used. Meanwhile, lots of problems were found in the clinical research, and the information reporting is not complete. Thus, the rationality and scientificity of integrative medicine need to be further studied. |
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