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| Study on inhibitory effect of Salvianolate on portal hypertension in liver cirrhosis |
| Hits 1653 Download times 1045 Received:July 10, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.12.20 |
| Key Words
Salvianolate;liver fibrosis;portal hypertension;DMN;colchicine |
| Author Name | Affiliation | | WU Xiangpeng | Sixth Department of General Surgery, Handan Central Hospital, Handan 056001, China | | CUI Wei | Handan Central Hospital, Handan 056001, China |
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| Abstract
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| [Objective] To investigate the inhibitoru effect of Salvianolate on liver fibrosis and portal hypertension in rats.[Methods] The liver fibrosis and portal hypertension model rats were made by peritoneal cavity injecting DMN, setting normal control group, model control group, Salvianolate[12, 24, 48 mg/(kg·d)] groups and Colchicine[0.1 mg/(kg·d)] group, 20 in each group. 6 weeks later, the content of ALT, AST, TBIL in serum were determined; the content of C-IV, PC-Ⅲ, LN, HA and the level of HYP in serum were determined; and the PVP, PVF, MAP, HR were detected; the histopathological changes of the hepatic tissue was observed by HE staining; the activity of SOD, CAT and the content of MDA in hepatic tissue were determined.[Results] After the Salvianolate[24, 48 mg/(kg.d)] were given for 6 weeks, the content of ALT, AST, TBIL, C-IV, PC-Ⅲ, HA, HYP in serum were significantly decreased (P<0.05 or P<0.01), the PVP, PVF were significantly decreased(P<0.05), the activity of SOD, CAT in hepatic tissue were significantly increased and the content of MDA were significantly decreased (P<0.05 or P<0.01). The content of LN in serum of Salvianolate[48 mg/(kg·d)] treated group was significantly decreased, the MAP was significantly increased and the HR was significantly decreased(P<0.05 or P<0.01). The hepatic histopathological changes of Salvianolate groups were significantly improved, especially the Salvianolate[48 mg/(kg·d)] group.[Conclusion] Salvianolate has inhibitory effects on liver fibrosis and portal hypertension in rats, which perhaps related to its effects of inhibiting the damage of oxidative stress. |
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